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Prevalence and determinations of physical inactivity among public hospital employees in Shanghai, China: a cross-sectionalstudy

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《医学前沿（英文）》 2015年 第9卷 第1期   页码 100-107 doi: 10.1007/s11684-014-0372-9

摘要：

This study aims to explore the prevalence and determinations of physical inactivity among hospital employees in Shanghai, China. A cross-sectional study of 4612 employees aged 19 to 68 years was conducted through stratified cluster sampling from different classes of Shanghai hospitals in 2011. The total physical activity was evaluated using the metabolic equivalent according to the Global Physical Activity Questionnaire. Among the participants, 38.5%, 32.3%, and 64.6% of the employees are inactive at work, commuting, and taking leisure time, respectively. Up to 41.8% of the men and 37.8% of the women (P = 0.012) are physically inactive. When the age and educational level are adjusted, male doctors and medical technicians show a higher percentage of physical inactivity than male workers in logistics (P = 0.001). Among females, employees who are working in second- and third-class hospitals show a higher proportion of physical inactivity than those who are working in community health care centers. Logistic regression analyses show that the odds ratios (ORs) of leisure-time physical inactivity associated with the intensity of physical activity at work are 2.259, 2.897, and 4.266 for men (P<0.001) and 2.456, 3.259, and 3.587 for women (P<0.001), respectively. The time during commuting activities is significantly associated with leisure-time physical inactivity in either sex (OR= 2.116 for men and 2.173 for women, P<0.001). Hospital employees, particularly doctors and medical technicians, show a higher proportion of physical inactivity than other inhabitants in Shanghai. The time and intensity of activity at work and commuting are associated with leisure-time activities.

关键词： prevalence     determination     employee     public hospital     cross-sectional study     physical inactivity    

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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic

《医学前沿（英文）》 doi: 10.1007/s11684-023-1022-x

摘要： The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans-retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a model for translational medicine research. Though an altered microenvironment is a general cancer hallmark, how APL blasts shape their plasma composition is poorly understood. Here, we reported a cross-sectional correlation network to interpret multilayered datasets on clinical parameters, proteomes, and metabolomes of paired plasma samples from patients with APL before or after ATRA/ATO induction therapy. Our study revealed the two prominent features of the APL plasma, suggesting a possible involvement of APL blasts in modulating plasma composition. One was characterized by altered secretory protein and metabolite profiles correlating with heightened proliferation and energy consumption in APL blasts, and the other featured APL plasma-enriched proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory targets of PML/RARA. Furthermore, results indicated heightened interferon-gamma signaling characterizing a tumor-suppressing function of the immune system at the first hematological complete remission stage, which likely resulted from therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular proteins. Overall, our work sheds new light on the pathophysiology and treatment of APL and provides an information-rich reference data cohort for the exploratory and translational study of leukemia microenvironment.

关键词： acute promyelocytic leukemia     plasma proteomics     plasma metabolomics     cross-sectional correlation network     pathogenesis     treatment    

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overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional

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《医学前沿（英文）》 2012年 第6卷 第3期   页码 322-328 doi: 10.1007/s11684-012-0204-8

摘要：

The aim of this study was to determine the prevalence of overweight and obese subjects in the Shanghai population of China and its association with undiagnosed hypertension, by taking age, gender and place of residence (urban or suburban) into account. A cross-sectional population-based survey was conducted in 2007. The sample included 13 359 participants aged 15–69 years. Weight, height, and blood pressure were recorded, and information about gender, age and place of residence was obtained. Overweight and obesity prevalence were calculated by the body mass index (BMI) definition recommended by Working Group on Obesity in China (normal weight, 18.5–23.9 kg/m2; overweight, 24–27.9 kg/m2; obesity,≥28 kg/m2). Undiagnosed hypertension was defined by China criteria in accord with that of WHO-ISH (subjects with systolic pressure≥140 mmHg, and/or diastolic pressure≥90 mmHg). Multiple logistic regression analyses were used to assess the association of overweight or obesity with undiagnosed hypertension by adjusting for age, gender and place of residence. The overall overweight, obesity, and undiagnosed hypertension prevalence were 27.6% (95% CI: 26.8–28.4), 6.6% (95% CI: 6.2–7.0), and 15.5% (95% CI: 14.9–16.1), respectively. Compared to normal weight subjects, the odds ratios (OR) for subjects who were overweight and had hypertension was 2.33 (95% CI: 2.10–2.59); that for obesity and hypertension was 4.27 (95% CI: 3.66–4.99). These data suggest that overweight and obesity prevalence and their association with undiagnosed hypertension are high in our study population.

关键词： overweight     obesity     undiagnosed hypertension     prevalence     association    

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Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

《医学前沿（英文）》 2022年 第16卷 第6期   页码 984-990 doi: 10.1007/s11684-022-0930-5

摘要： Nonpharmaceutical interventions (NPIs) have been commonly deployed to prevent and control the spread of the coronavirus disease 2019 (COVID-19), resulting in a worldwide decline in influenza prevalence. However, the influenza risk in China warrants cautious assessment. We conducted a cross-sectional, sero-epidemiological study in Shandong Province, Northern China in mid-2021. Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains. A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic. The overall seroprevalence values against A/H1N1pdm09, A/H3N2, B/Victoria, and B/Yamagata were 17.8% (95% CI 16.2%–19.5%), 23.5% (95% CI 21.7%–25.4%), 7.6% (95% CI 6.6%–8.7%), and 15.0 (95% CI 13.5%–16.5%), respectively, in the study period. The overall vaccination rate was extremely low (2.6%). Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals (P < 0.001). Notably, the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic ( P < 0.01). Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.

关键词： influenza virus     seroprevalence     antibody     COVID-19     cross-sectional study    

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Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

《医学前沿（英文）》 2022年 第16卷 第6期   页码 969-974 doi: 10.1007/s11684-021-0912-z

摘要： Malaria is highly prevalent in Nigeria and accounts for approximately 40% of global malaria mortality. However, most reports on severe malaria in Nigeria are from hospital-based studies without accurate information from communities; thus, malaria-related deaths in the community are left untracked. This study aimed to describe the prevalence and pattern of severe malaria in a community in Northwestern Nigeria. A cross-sectional study was conducted among 2–10-year-old children in Sokoto, in August and December 2016, to determine the endemicity of malaria based on Plasmodium falciparum prevalence rate (PfPR2-10) and to describe the disease pattern. Severe malaria was diagnosed according to the World Health Organisation criteria. Data were described using Stata version 15. The prevalence of non-anaemia severe malaria was higher than expected (2.6%), considering the endemicity pattern which was mesoendemic based on a PfPR2-10 of 34.8%. The mean age of children with severe malaria was 3.73 years, and the male–female ratio was 2:1. However, 54.0% of the patients had hyperparasitaemia. A relatively high prevalence of non-anaemia severe malaria was found in Wamakko. This finding suggests the need to identify and treat cases in the community using modifications of current strategies, particularly seasonal malaria chemoprophylaxis.

关键词： severe malaria     nigeria     malaria mortality     PfPR2-10     intermediate malaria transmission    

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terminating the Bacillus Calmette--Guérin booster vaccination: subgroup analysis of a population-based cross-sectionalstudy

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《医学前沿（英文）》 2017年 第11卷 第4期   页码 528-535 doi: 10.1007/s11684-017-0573-0

摘要：

The prevalence of tuberculosis infection among adolescents born after terminating the Bacillus Calmette–Guérin (BCG) booster vaccination in China was estimated using tuberculin skin testing (TST) and QuantiFERON-TB Gold assay (QFT) to investigate the influence of neonatal BCG vaccination on the performance of TST. Data analysis was conducted for 2831 eligible participants aged 5–15 years from the baseline survey of a population-based multi-center prospective study. The prevalence rates of TST (induration≥10 mm) and QFT positivity were 9.3% (264/2827) and 2.5% (71/2831), respectively. The rate of QFT indeterminate result was 2.2% (62/2831). The overall agreement between TST and QFT was low (concordance= 88.0%; κ coefficient= 0.125). Only TST was positively associated with BCG vaccination with an adjusted odds ratio of 1.71 [95% confidence interval, 1.26–2.31]. A history of close contact with patients of active TB was significantly associated with positivity for TST and QFT. Our results suggested that BCG neonatal vaccination still affects TST performance, and a two-step approach might be considered for TB infection testing among adolescents in China.

关键词： tuberculin skin test     interferon-γ release assays     adolescent     agreement    

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between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes mellitus: a cross-sectionalcohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

《医学前沿（英文）》 2020年 第14卷 第5期   页码 642-650 doi: 10.1007/s11684-019-0719-3

摘要： This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinine ratio (UACR) in patients with type 2 diabetes mellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabetic kidney disease (DKD). A total of 390 patients with T2DM were divided into three groups: normal albuminuria (UACR<30 mg/g, =136, NA), microalbuminuria (UACR at 30–300 mg/g, =132, MA), and clinical albuminuria (UACR>300 mg/g, =122, CA). Circulating miR-154-5p, inflammatory (C-reactive protein (CRP); erythrocyte sedimentation rate (ESR); and tumor necrosis factor-α (TNF-α) and fibrotic markers (vascular endothelial growth factor (VEGF); transforming growth factor-β1 (TGF-β1); and fibronectin (FN)), and other biochemical indicators were assessed via real-time PCR, enzyme-linked immunosorbent assay, and chemiluminescence assay in patients with T2DM and 138 control subjects (NC). UACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were significantly higher and the estimated glomerular filtration rate (eGFR) was significantly lower in NA, MA, and CA groups than in NC subjects ( <0.05). Elevated levels of UACR and miR-154-5p were directly correlated with HbA1c, sCr, BUN, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN and negatively correlated with eGFR ( <0.05). miR-154-5p, HbA1c, sCr, BUN, eGFR, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were important factors affecting UACR. These findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in patients with T2DM and may offer a novel reference for the early diagnosis of DKD.

关键词： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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An automated arc spray tooling system for rapid die-making of large-sized automobile body panels

HE Zhong-yun, LU Bing-heng, WANG Yi-qing, HONG Jun, TANG Yi-ping

《机械工程前沿（英文）》 2006年 第1卷 第2期   页码 209-214 doi: 10.1007/s11465-006-0012-4

摘要： A creative robot wrist consisting of link mechanisms and a novel robot motion control method based on the cross-sectional vector contours of an STL-formatted model was proposed. By using the wrist and the control method, an industrial robot with five degrees of freedom for rapid tooling using metal arc spraying and electric brush plating techniques was developed. The wrist of the robot including a specially designed link mechanism can maintain the position of the spraying point on the surface of the master pattern whatever the orientation of the gun. Therefore, the kinematic nonlinear coupling between the position mechanism and orientation mechanism in a traditional robot can be avoided. The only input of the control system is the STL-formatted 3D CAD model of the pattern. Without the need of any manual programming, the metal arc spraying and brush plating (if necessary) processes can be performed automatically and efficiently after receiving the 3D CAD data of the pattern. Using this robot system in new car development and trial production, the cost and lead-time can be reduced substantially as compared with the conventional tool making method.

关键词： industrial     position mechanism     orientation     surface     cross-sectional    

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Sectional model test study on vortex-excited resonance of vehicle-bridge system of Shanghai Bridge over

Li ZHOU, Yaojun GE

《结构与土木工程前沿（英文）》 2009年 第3卷 第1期   页码 67-72 doi: 10.1007/s11709-009-0007-4

摘要： It is necessary to study how vehicles influence the vortex-excited resonance of vehicle-bridge systems, because lock-in wind speed is low and vortex-excited resonance is sensitive to any change in the main girder sections. Based on the Shanghai Bridge over the Yangtse River, the vortex-excited resonance of a 1∶60 scale sectional model was tested in a TJ-1wind tunnel, with or without vehicles at the attack angle of 0°, +3 and -3°, respectively. The conversion relationships between the resonant amplitudes of the sectional model and that of the prototype bridge were also established by mode shape correction. The result indicates that: 1) for the bridge with vehicles, the vertical vortex-excited resonance is accompanied by torsion vibration with the same frequency, and vice versa, 2) the amplitude of vortex-excited resonance of the bridge with vehicles is much larger than that of the bridge without vehicles, and 3) the lock-in wind speed of the vortex-excited resonance becomes smaller due to the disturbance of vehicles. It is obvious that vehicles bring about changes in the aerodynamic shape of the main girder. Therefore, the influence of vehicles on vortex-excited resonance performance of vehicle-bridge systems, in terms of both amplitude and mode, should not be ignored.

关键词： vehicle-bridge system     sectional mode     vortex-excited resonance     wind tunnel test     mode shape correction    

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Experimental study on the temperature dependence of ultraviolet absorption cross-sections of sulfur dioxide

ZHANG Shiliang, ZHOU Jie, CHEN Xiaohu

《能源前沿（英文）》 2008年 第2卷 第2期   页码 183-186 doi: 10.1007/s11708-008-0025-2

摘要： The photoabsorption cross-sections of sulfur dioxide were measured in the spectral regions of 200–230 nm and 275–315 nm at 298–415 K, using a grating monochromator with a resolution of 0.2 nm. The discrete absorption cross-section is directly correlated with the number of quantum excited from the base state. The absorption cross-sections at the peaks of discrete bands decreased linearly with the increase of temperature, which corresponded to the decrease in the population of vibrational and rotational transitions from the base level to higher excitation levels. The absorption cross-section peaks decreased linearly when the temperature increased from 298 to 415 K, with relative drops of 74.0% and 75.8% at 200–230 nm and 275–315 nm, respectively. Another distinctive feature of sulfur dioxide absorption spectra in the above two spectral regions was the quasiperiodic structure of the absorption peaks, whose equal wavelength intervals were 1.53 nm and 1.95 nm, respectively. Red and blue shifts were not found at the absorption peak positions.
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渤海海峡跨海隧道方案研究

谭忠盛,王梦恕

《中国工程科学》 2013年 第15卷 第12期   页码 45-51

摘要：

渤海海峡固定式跨海工程是国家铁路网和高速公路的重要组成部分，跨海通道建成后将取代现有的轮渡运输方式，满足不断增长的交通运输的需求，并会进一步加快环渤海经济圈的发展以及东北老工业基地的振兴。在研究渤海海峡的气象、水文、地质等建设条件的基础上，对桥隧工程方案及隧道线位方案进行了初步比选分析，认为渤海海峡跨海工程宜采用全隧道方案，并且旅顺－蓬莱的隧道连岛线位方案较优，在对该线位浅埋隧道和深埋隧道比较后认为采用深埋方案较优。由于公路隧道存在诸多技术难题，以及工程造价和运营成本都很高，因此，把铁路隧道方案作为首选方案，汽车可通过穿梭列车背负式通过隧道。

关键词： 渤海海峡     跨海工程     铁路隧道     初步方案    

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Study of two-phase flow regime identification in horizontal tube bundles under vertical upward cross-flow

HUANG Xinghua, WANG Li, JIA Feng

《能源前沿（英文）》 2008年 第2卷 第3期   页码 333-338 doi: 10.1007/s11708-008-0043-0

摘要： A wavelet-transform based approach for flow regime identification in horizontal tube bundles under vertical upward cross-flow condition was presented. Tests on two-phase flow pattern of R134a were conducted under low mass velocity and flow boiling conditions over ranges of mass flux 4–25 kg/ms, vapor quality 0.02–0.90. Time series of differential pressure fluctuations were measured and analyzed with discrete wavelet transform. Different time-scale characteristics in bubbly flow, churn flow and annular flow were analyzed. The wavelet energy distributions over scales were found to be appropriate for flow regime identification. Based on the wavelet energy distribution over characteristic scales, a criterion of flow regime identification was proposed. The comparison with experiment results show that it is feasible to use the discrete wavelet transform as the tool of flow regime identification in horizontal tube bundles under vertical upward cross-flow condition.

关键词： two-phase     discrete     appropriate     wavelet-transform     criterion    

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渤海海峡跨海通道桥隧方案比选研究

宋克志

《中国工程科学》 2013年 第15卷 第12期   页码 52-60

摘要：

从对航空及航运的影响、通行能力和行车舒适性、行车安全与气候适应性、施工难度及工程风险等方面对桥梁、隧道方案各自的技术特性进行了分析与比较。从技术角度考虑，桥隧方案皆具有实施的可行性，隧道在航运影响、气候适应性、生态环境等方面明显优于桥梁，而桥梁则在通行能力、施工难度和风险、运营成本、行车安全、行车舒适性、景观效果等方面优于隧道。随后，运用层次分析法建立了渤海海峡跨海通道比较评价的指标体系，并确定了各指标的权重系数。通过专家打分法和隶属度函数取得各定性指标和定量指标的隶属度，最后运用模糊综合评价模型计算全桥梁、全隧道及桥隧组合方案的模糊综合评价值，全隧道方案评价得分最高，因此，推荐渤海海峡跨海通道采用全隧道方案。

关键词： 桥梁与隧道工程     跨海通道     渤海海峡     方案比选     模糊综合评价    

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Methods and applications of DEA cross-efficiency: Review and future perspectives

Jie WU, Jiasen SUN, Liang LIANG

《工程管理前沿（英文）》 2021年 第8卷 第2期   页码 199-211 doi: 10.1007/s42524-020-0133-1

摘要： The field of engineering management usually involves evaluation issues, such as program selection, team performance evaluation, technology selection, and supplier evaluation. The traditional self-evaluation data envelopment analysis (DEA) method usually exaggerates the effects of several inputs or outputs of the evaluated decision-making unit (DMU), resulting in unrealistic results. To address this problem, scholars have proposed the cross-efficiency evaluation (CREE) method. Compared with the DEA method, CREE can rank DMUs more completely by using reasonable weights. With the extensive application of this technique, several problems, such as non-unique weights and non-Pareto optimal results, have arisen in CREE methods. Therefore, the improvement of CREE has attracted the attention of many scholars. This paper reviews the theory and applications of CREE, including the non-uniqueness problem, the aggregation of cross-efficiency data, and applications in engineering management. It also discusses the directions for future research on CREE.

关键词： cross-efficiency evaluation     efficiency     secondary goal model     aggregation     review    

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River Chief System (RCS): An experiment on cross-sectoral coordination of watershed governance

Longfei Wang, Jiaxin Tong, Yi Li

《环境科学与工程前沿（英文）》 2019年 第13卷 第4期 doi: 10.1007/s11783-019-1157-9

摘要：

The trans-regional characteristics of watershed governance produce more problems beyond the capacity of each individual water-related department, leading to the fragmentation of watershed management. The River Chief System (RCS) has experienced swift developments over the past decade in China by appointing the local government heads as river chiefs. RCS works efficiently in the short-term due to its superiority in the inclusion of clear responsibility, authority, and multi-sectoral collaboration. However, the characteristics of the authority-based vertical coordination of the hierarchical system remain unchanged, and therefore the problems of organizational logic and the responsibility dilemma still exist. Tasks including perfecting of laws, integrated watershed management, and public participation still need to be completed. RCS reflects the routine and characteristics of the migration of national governance, and as such provides new insights for other developing countries in the design of river management systems.

关键词： River Chief System     Watershed governance     Cross-sectoral coordination     Environmental protection    

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标题 作者 时间 类型 操作

Prevalence and determinations of physical inactivity among public hospital employees in Shanghai, China: a cross-sectionalstudy

null

期刊论文

Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic

期刊论文

overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional

null

期刊论文

Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

期刊论文

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

期刊论文

terminating the Bacillus Calmette--Guérin booster vaccination: subgroup analysis of a population-based cross-sectionalstudy

null

期刊论文

between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes mellitus: a cross-sectionalcohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

期刊论文

An automated arc spray tooling system for rapid die-making of large-sized automobile body panels

HE Zhong-yun, LU Bing-heng, WANG Yi-qing, HONG Jun, TANG Yi-ping

期刊论文

Sectional model test study on vortex-excited resonance of vehicle-bridge system of Shanghai Bridge over

Li ZHOU, Yaojun GE

期刊论文

Experimental study on the temperature dependence of ultraviolet absorption cross-sections of sulfur dioxide

ZHANG Shiliang, ZHOU Jie, CHEN Xiaohu

期刊论文

渤海海峡跨海隧道方案研究

谭忠盛,王梦恕

期刊论文

Study of two-phase flow regime identification in horizontal tube bundles under vertical upward cross-flow

HUANG Xinghua, WANG Li, JIA Feng

期刊论文

渤海海峡跨海通道桥隧方案比选研究

宋克志

期刊论文

Methods and applications of DEA cross-efficiency: Review and future perspectives

Jie WU, Jiasen SUN, Liang LIANG

期刊论文

River Chief System (RCS): An experiment on cross-sectoral coordination of watershed governance

Longfei Wang, Jiaxin Tong, Yi Li

期刊论文